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The antibody against MIB2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 300-580 of human MIB2 (NP_001164158.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against MIB2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 300-580 of human MIB2 (NP_001164158.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
| Cat.No | ADA-10527A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MIB2 |
| Target Synonyms | ZZZ5; ZZANK1; MIB2 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, Rat brain, BxPC-3, Mouse brain, Mouse lung, Mouse testis, Rat testis, U-87MG | Application | ELISA, WB, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 300-580 of human MIB2 (NP_001164158.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q96AX9 | Immunogen Sequence |
Uniprot Id
Q96AX9
Target Species
Human
Target Name
MIB2
Target Full Name
E3 ubiquitin-protein ligase MIB2
Target Function
E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors.
Target Subcellular Location
Cytoplasm. Endosome. Note=Colocalizes with endosomal compartments.
Target Tissue Specificity
Expressed in skeletal muscle, and to a lesser extent in heart, brain and kidney.
Target Synonyms
MIB2; SKD; ZZANK1; E3 ubiquitin-protein ligase MIB2; EC 2.3.2.27; Mind bomb homolog 2; Novel zinc finger protein; Novelzin; Putative NF-kappa-B-activating protein 002N; RING-type E3 ubiquitin transferase MIB2; Skeletrophin; Zinc finger ZZ type with ankyrin repeat domain protein 1
Target Background
The protein encoded by this gene is an E3 ubiquitin protein ligase that mediates ubiquitination of proteins in the Notch signaling pathway. The encoded protein may be a suppressor of melanoma invasion.
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