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The antibody against MTA3 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 40-330 of human MTA3 (NP_065795.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
The antibody against MTA3 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 40-330 of human MTA3 (NP_065795.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
Immunohistochemistry analysis of paraffin-embedded rat liver using MTA3 antibody at dilution of 1:100 (40x lens).Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
| Cat.No | ADA-02902A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MTA3 |
| Target Synonyms | MTA3 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, A-549, HepG2 | Application | ELISA, WB, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 40-330 of human MTA3 (NP_065795.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9BTC8 | Immunogen Sequence |
Uniprot Id
Q9BTC8
Target Species
Human
Target Name
MTA3
Target Full Name
Metastasis-associated protein MTA3
Target Function
Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels. Contributes to transcriptional repression by BCL6.
Target Subcellular Location
Nucleus.
Target Tissue Specificity
Expressed in germinal centers of lymphoid tissues. No expression in nonepithelial cells.
Target Synonyms
1110002J22Rik; fj99h01; KIAA1266; Metastasis associated 1 family, member 3; Metastasis associated 3; Metastasis associated family, member 3; Metastasis associated gene 3; Metastasis associated gene family, member 3; Metastasis associated protein MTA3; Metastasis-associated protein MTA3; MGC56396; MGC77410; mKIAA1266; mta1; Mta3; MTA3 metastasis associated 1 family, member 3; Mta3 metastasis associated 3; MTA3_HUMAN; wu:fj99h01; zgc:56396
Target Background
Predicted to enable histone deacetylase binding activity; transcription coactivator activity; and transcription corepressor activity. Involved in negative regulation of transcription, DNA-templated. Located in nucleoplasm. Part of NuRD complex.
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