Rabbit anti-Human MTPAP Polyclonal Antibody

The antibody against MTPAP was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 383-582 of human MTPAP (NP_060579.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-07041A

Number

Cat.No	ADA-07041A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	MTPAP
Target Synonyms	PAPD1; SPAX4; TENT6; MTPAP	Form	Liquid
Species Reactivity	Human, Mouse	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.01% thimerosal, pH7.3.	Purification Method	Affinity purification
Positive Samples	Jurkat, Mouse spleen, U-251MG, U-87MG	Application	ELISA, WB

Cat.No

ADA-07041A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

MTPAP

Target Synonyms

PAPD1; SPAX4; TENT6; MTPAP

Form

Liquid

Species Reactivity

Human, Mouse

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.01% thimerosal, pH7.3.

Purification Method

Affinity purification

Positive Samples

Jurkat, Mouse spleen, U-251MG, U-87MG

Application

ELISA, WB

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 383-582 of human MTPAP (NP_060579.3).	Target Species	Human
Immunogen Sequence	MVIFFLQRRSPPILPTLDSLKTLADAEDKCVIEGNNCTFVRDLSRIKPSQNTETLELLLKEFFEYFGNFAFDKNSINIRQGREQNKPDSSPLYIQNPFETSLNISKNVSQSQLQKFVDLARESAWILQQEDTDRPSISSNRPWGLVSLLLPSAPNRKSFTKKKSNKFAIETVKNLLESLKGNRTENFTKTSGKRTISTQT	Uniprot ID	Q9NVV4

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 383-582 of human MTPAP (NP_060579.3).

Target Species

Human

Immunogen Sequence

MVIFFLQRRSPPILPTLDSLKTLADAEDKCVIEGNNCTFVRDLSRIKPSQNTETLELLLKEFFEYFGNFAFDKNSINIRQGREQNKPDSSPLYIQNPFETSLNISKNVSQSQLQKFVDLARESAWILQQEDTDRPSISSNRPWGLVSLLLPSAPNRKSFTKKKSNKFAIETVKNLLESLKGNRTENFTKTSGKRTISTQT

Uniprot ID

Q9NVV4

Background Information

Uniprot Id

Q9NVV4
Target Species

Human
Target Name

MTPAP
Target Full Name

Poly(A) RNA polymerase, mitochondrial
Target Function

Polymerase that creates the 3' poly(A) tail of mitochondrial transcripts. Can use all four nucleotides, but has higher activity with ATP and UTP (in vitro). Plays a role in replication-dependent histone mRNA degradation. May be involved in the terminal uridylation of mature histone mRNAs before their degradation is initiated. Might be responsible for the creation of some UAA stop codons which are not encoded in mtDNA.
Target Involvement

Spastic ataxia 4, autosomal recessive (SPAX4)
Target Subcellular Location

Cytoplasm. Mitochondrion.
Target Protein Families

DNA polymerase type-B-like family
Target Tissue Specificity

Ubiquitous, with stronger expression in tissues with high energy requirements: heart, brain, and skeletal muscle.
Target Synonyms

0610027A18Rik; AW551379; EC 2.7.7.19; FLJ10486; mitochondrial; Mitochondrial poly(A) polymerase; mtPAP; PAP; PAP-associated domain-containing protein 1; PAPD1; PAPD1_HUMAN; Poly(A) RNA polymerase; Poly(A) RNA polymerase, mitochondrial; Poly(A) RNA polymerase, mitochondrial precursor; Polynucleotide adenylyltransferase; RP11-305E6.3; Terminal uridylyltransferase 1; TUTase 1
Target Background

The protein encoded by this gene is a member of the DNA polymerase type-B-like family. This enzyme synthesizes the 3' poly(A) tail of mitochondrial transcripts and plays a role in replication-dependent histone mRNA degradation.

Rabbit anti-Human MTPAP Polyclonal Antibody

Specifications

Immunogen Information

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