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The antibody against PHACTR1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 154-380 of human PHACTR1 (NP_112210.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against PHACTR1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 154-380 of human PHACTR1 (NP_112210.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-07384A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PHACTR1 |
| Target Synonyms | RPEL; DEE70; RPEL1; EIEE70; dJ257A7.2; PHACTR1 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | C6, Rat brain, Mouse brain, SH-SY5Y, U-251MG, U-87MG | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 154-380 of human PHACTR1 (NP_112210.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9C0D0 | Immunogen Sequence |
Uniprot Id
Q9C0D0
Target Species
Human
Target Name
PHACTR1
Target Full Name
Phosphatase and actin regulator 1
Target Function
Binds actin monomers (G actin) and plays a role in multiple processes including the regulation of actin cytoskeleton dynamics, actin stress fibers formation, cell motility and survival, formation of tubules by endothelial cells, and regulation of PPP1CA activity. Involved in the regulation of cortical neuron migration and dendrite arborization.
Target Subcellular Location
Cytoplasm. Cell junction, synapse. Nucleus.
Target Protein Families
Phosphatase and actin regulator family
Target Tissue Specificity
Detected in umbilical vein endothelial cells.
Target Synonyms
PHACTR1; KIAA1733; RPEL1; Phosphatase and actin regulator 1
Target Background
The protein encoded by this gene is a member of the phosphatase and actin regulator family of proteins. This family member can bind actin and regulate the reorganization of the actin cytoskeleton. It plays a role in tubule formation and in endothelial cell survival. Polymorphisms in this gene are associated with susceptibility to myocardial infarction, coronary artery disease and cervical artery dissection. Alternative splicing of this gene results in multiple transcript variants.
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