Rabbit anti-Human POU4F3 Polyclonal Antibody

Uniprot Id

Q15319

Target Species

Human

Target Name

POU4F3

Target Full Name

POU domain, class 4, transcription factor 3

Target Function

Acts as a transcriptional activator. Acts by binding to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes. Involved in the auditory system development, required for terminal differentiation of hair cells in the inner ear.

Target Involvement

Deafness, autosomal dominant, 15 (DFNA15)

Target Subcellular Location

Nucleus. Cytoplasm.

Target Protein Families

POU transcription factor family, Class-4 subfamily

Target Tissue Specificity

Brain. Seems to be specific to the retina.

Target Synonyms

Brain specific homeobox/POU domain protein 3C; Brain-3C; Brain-specific homeobox/POU domain protein 3C; BRN 3C; Brn-3C; BRN3C; class 4; DFNA 15; DFNA15; MGC138412; PO4F3_HUMAN; POU class 4 homeobox 3; POU domain; POU domain class 4 transcription factor 3; POU4F3; transcription factor 3

Target Background

This gene encodes a member of the POU-domain family of transcription factors. POU-domain proteins have been observed to play important roles in control of cell identity in several systems. This protein is found in the retina and may play a role in determining or maintaining the identities of a small subset of visual system neurons. Defects in this gene are the cause of non-syndromic sensorineural deafness autosomal dominant type 15.