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The antibody against PPOX was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human PPOX (NP_001116236.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
The antibody against PPOX was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human PPOX (NP_001116236.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
| Cat.No | ADA-03050A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PPOX |
| Target Synonyms | VP; PPO; V290M; PPOX | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse kidney, HepG2, Mouse liver, Mouse spleen | Application | ELISA, WB, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human PPOX (NP_001116236.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P50336 | Immunogen Sequence |
Uniprot Id
P50336
Target Species
Human
Target Name
PPOX
Target Full Name
Protoporphyrinogen oxidase
Target Function
Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
Target Involvement
Variegate porphyria (VP)
Target Subcellular Location
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
Target Protein Families
Protoporphyrinogen oxidase family
Target Tissue Specificity
Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Target Research Area
Metabolism
Target Synonyms
MGC8485; PPO; PPOX; PPOX_HUMAN; Protoporphyrinogen oxidase; V290M; Variegate porphyria; VP
Target Background
This gene encodes the penultimate enzyme of heme biosynthesis, which catalyzes the 6-electron oxidation of protoporphyrinogen IX to form protoporphyrin IX. Mutations in this gene cause variegate porphyria, an autosomal dominant disorder of heme metabolism resulting from a deficiency in protoporphyrinogen oxidase, an enzyme located on the inner mitochondrial membrane. Alternatively spliced transcript variants encoding the same protein have been identified.
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