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The antibody against PTS was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-145 of human PTS (NP_000308.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against PTS was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-145 of human PTS (NP_000308.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-03098A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PTS |
| Target Synonyms | PTPS; PTS | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, Mouse kidney, Mouse liver, U-251MG | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-145 of human PTS (NP_000308.1). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | MSTEGGGRRCQAQVSRRISFSASHRLYSKFLSDEENLKLFGKCNNPNGHGHNYKVVVTVHGEIDPATGMVMNLADLKKYMEEAIMQPLDHKNLDMDVPYFADVVSTTENVAVYIWDNLQKVLPVGVLYKVKVYETDNNIVVYKGE | Uniprot ID | Q03393 |
Uniprot Id
Q03393
Target Species
Human
Target Name
PTS
Target Full Name
6-pyruvoyl tetrahydrobiopterin synthase
Target Function
Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin.
Target Involvement
Hyperphenylalaninemia, BH4-deficient, A (HPABH4A)
Target Protein Families
PTPS family
Target Synonyms
PTPS; PTS
Target Background
The enzyme encoded by this gene catalyzes the elimination of inorganic triphosphate from dihydroneopterin triphosphate, which is the second and irreversible step in the biosynthesis of tetrahydrobiopterin from GTP. Tetrahydrobiopterin, also known as BH(4), is an essential cofactor and regulator of various enzyme activities, including enzymes involved in serotonin biosynthesis and NO synthase activity. Mutations in this gene result in hyperphenylalaninemia.
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