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The antibody against PYGB was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 544-843 of human PYGB (NP_002853.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against PYGB was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 544-843 of human PYGB (NP_002853.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-06188A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PYGB |
| Target Synonyms | GPBB; PYGB | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Rat brain, BT-474, HepG2, Mouse lung, SW620 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 544-843 of human PYGB (NP_002853.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P11216 | Immunogen Sequence |
Uniprot Id
P11216
Target Species
Human
Target Name
PYGB
Target Full Name
Glycogen phosphorylase, brain form
Target Function
Glycogen phosphorylase that regulates glycogen mobilization. Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.
Target Protein Families
Glycogen phosphorylase family
Target Research Area
Metabolism
Target Synonyms
Brain glycogen phosphorylase; Glycogen phosphorylase B; Glycogen phosphorylase brain form; Glycogen Phosphorylase Isoenzyme BB; Glycogen phosphorylase; brain form; MGC9213; Phosphorylase glycogen brain; PYGB; PYGB_HUMAN
Target Background
The protein encoded by this gene is a glycogen phosphorylase found predominantly in the brain. The encoded protein forms homodimers which can associate into homotetramers, the enzymatically active form of glycogen phosphorylase. The activity of this enzyme is positively regulated by AMP and negatively regulated by ATP, ADP, and glucose-6-phosphate. This enzyme catalyzes the rate-determining step in glycogen degradation.
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