Rabbit anti-Human RAPGEF4 Polyclonal Antibody

The antibody against RAPGEF4 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human RAPGEF4 (NP_001093867.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-03945A

Number

Cat.No	ADA-03945A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	RAPGEF4
Target Synonyms	EPAC; CGEF2; EPAC2; EPAC 2; Nbla00496; CAMP-GEFII; RAPGEF4	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	Rat brain, Mouse brain, SH-SY5Y, SW620	Application	ELISA, WB

Cat.No

ADA-03945A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

RAPGEF4

Target Synonyms

EPAC; CGEF2; EPAC2; EPAC 2; Nbla00496; CAMP-GEFII; RAPGEF4

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

Rat brain, Mouse brain, SH-SY5Y, SW620

Application

ELISA, WB

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human RAPGEF4 (NP_001093867.1).	Target Species	Human
Uniprot ID	Q8WZA2	Immunogen Sequence

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human RAPGEF4 (NP_001093867.1).

Target Species

Human

Uniprot ID

Q8WZA2

Immunogen Sequence

Background Information

Uniprot Id

Q8WZA2
Target Species

Human
Target Name

RAPGEF4
Target Full Name

Rap guanine nucleotide exchange factor 4
Target Function

Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2.
Target Subcellular Location

Cytoplasm. Membrane; Peripheral membrane protein.
Target Tissue Specificity

Predominantly expressed in brain and adrenal gland. Isoform 2 is expressed in liver. Isoform 1 is expressed in liver at very low levels.
Target Synonyms

CAMP GEFII; cAMP regulated guanine nucleotide exchange factor II; cAMP-GEFII; cAMP-regulated guanine nucleotide exchange factor II; CAMPGEFII; CGEF 2; CGEF2; Epac 2; EPAC2; Exchange factor directly activated by cAMP 2; Exchange protein directly activated by cAMP 2; Nbla00496; Putative protein product of Nbla00496; Rap guanine nucleotide exchange factor (GEF) 4; Rap guanine nucleotide exchange factor 4; RAPGEF 4; Rapgef4; RPGF4_HUMAN
Target Background

Enables guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane and regulation of postsynapse organization. Predicted to act upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway; regulation of exocytosis; and secretion by cell. Predicted to be located in plasma membrane. Predicted to be active in glutamatergic synapse; hippocampal mossy fiber to CA3 synapse; and postsynaptic density. Implicated in autistic disorder.

Rabbit anti-Human RAPGEF4 Polyclonal Antibody

Specifications

Immunogen Information

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