Rabbit anti-Human RRBP1 Polyclonal Antibody

Uniprot Id

Q9P2E9

Target Species

Human

Target Name

RRBP1

Target Full Name

Ribosome-binding protein 1

Target Function

Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane.

Target Subcellular Location

Endoplasmic reticulum membrane; Single-pass type III membrane protein.

Target Synonyms

180 kDa ribosome receptor homolog; DKFZp586A1420; ES/130; ES/130 related protein; ES/130-related protein; ES130; FLJ36146; hES; KIAA1398; MGC157720; MGC157721; Ribosome binding protein 1; Ribosome binding protein 1 homolog 180kDa; Ribosome binding protein 1 homolog; Ribosome receptor protein; Ribosome-binding protein 1; RRBP 1; Rrbp1; RRBP1_HUMAN; RRP

Target Background

This gene encodes a ribosome-binding protein of the endoplasmic reticulum (ER) membrane. Studies suggest that this gene plays a role in ER proliferation, secretory pathways and secretory cell differentiation, and mediation of ER-microtubule interactions. Alternative splicing has been observed and protein isoforms are characterized by regions of N-terminal decapeptide and C-terminal heptad repeats. Splicing of the tandem repeats results in variations in ribosome-binding affinity and secretory function. The full-length nature of variants which differ in repeat length has not been determined. Pseudogenes of this gene have been identified on chromosomes 3 and 7, and RRBP1 has been excluded as a candidate gene in the cause of Alagille syndrome, the result of a mutation in a nearby gene on chromosome 20p12.