Rabbit anti-Human SOX17 Polyclonal Antibody

Uniprot Id

Q9H6I2

Target Species

Human

Target Name

SOX17

Target Full Name

Transcription factor SOX-17

Target Function

Acts as transcription regulator that binds target promoter DNA and bends the DNA. Binds to the sequences 5'-AACAAT-'3 or 5'-AACAAAG-3'. Modulates transcriptional regulation via WNT3A. Inhibits Wnt signaling. Promotes degradation of activated CTNNB1. Plays a key role in the regulation of embryonic development. Required for normal development of the definitive gut endoderm. Required for normal looping of the embryonic heart tube. Plays an important role in embryonic and postnatal vascular development, including development of arteries. Plays an important role in postnatal angiogenesis, where it is functionally redundant with SOX18. Required for the generation and maintenance of fetal hematopoietic stem cells, and for fetal hematopoiesis. Probable transcriptional activator in the premeiotic germ cells.

Target Involvement

Vesicoureteral reflux 3 (VUR3)

Target Subcellular Location

Nucleus.

Target Tissue Specificity

Expressed in adult heart, lung, spleen, testis, ovary, placenta, fetal lung, and kidney. In normal gastrointestinal tract, it is preferentially expressed in esophagus, stomach and small intestine than in colon and rectum.

Target Synonyms

FLJ22252; SOX17; SOX17_HUMAN; SRY (sex determining region Y) box 17; SRY box 17 ; SRY related HMG box transcription factor SOX17; Transcription factor SOX-17; Transcription factor SOX17; VUR3

Target Background

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins.