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The antibody against TCTN3 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 200-475 of human TCTN3 (NP_056446.4) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against TCTN3 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 200-475 of human TCTN3 (NP_056446.4) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-06508A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TCTN3 |
| Target Synonyms | OFD4; TECT3; JBTS18; C10orf61; TCTN3 | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse brain, Mouse craniofacial, Mouse lung | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 200-475 of human TCTN3 (NP_056446.4). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q6NUS6 | Immunogen Sequence |
Uniprot Id
Q6NUS6
Target Species
Human
Target Name
TCTN3
Target Full Name
Tectonic-3
Target Function
Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. May be involved in apoptosis regulation. Necessary for signal transduction through the sonic hedgehog (Shh) signaling pathway.
Target Involvement
Orofaciodigital syndrome 4 (OFD4); Joubert syndrome 18 (JBTS18)
Target Subcellular Location
Membrane; Single-pass type I membrane protein.
Target Protein Families
Tectonic family
Target Synonyms
C10orf61; Chromosome 10 open reading frame 61; DKFZP564D116; JBTS18; OFD4; TCTN3; TECT3; TECT3_HUMAN; Tectonic 3; Tectonic 3 precursor; Tectonic family member 3; Tectonic-3
Target Background
This gene encodes a member of the tectonic gene family which functions in Hedgehog signal transduction and development of the neural tube. Mutations in this gene have been associated with Orofaciodigital Syndrome IV and Joubert Syndrom 18. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
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