Rabbit anti-Human TRAF7 Polyclonal Antibody

Uniprot Id

Q6Q0C0

Target Species

Human

Target Name

TRAF7

Target Full Name

E3 ubiquitin-protein ligase TRAF7

Target Function

E3 ubiquitin ligase capable of auto-ubiquitination, following phosphorylation by MAP3K3. Potentiates MAP3K3-mediated activation of the NF-kappa-B, JUN/AP1 and DDIT3 transcriptional regulators. Induces apoptosis when overexpressed. Plays a role in the phosphorylation of MAPK1 and/or MAPK3, probably via its interaction with MAP3K3.

Target Subcellular Location

Cytoplasmic vesicle. Note=Colocalizes with MAP3K3 to vesicle-like structures throughout the cytoplasm.

Target Protein Families

WD repeat TRAF7 family

Target Tissue Specificity

Ubiquitously expressed with high levels in skeletal muscle, heart, colon, spleen, kidney, liver and placenta.

Target Synonyms

E3 ubiquitin protein ligase TRAF7; E3 ubiquitin-protein ligase TRAF7; RFWD1; Ring finger and WD repeat domain 1; RING finger and WD repeat-containing protein 1; RING finger protein 119; RNF119; TNF receptor associated factor 7; TNF receptor-associated factor 7; TRAF7; TRAF7_HUMAN

Target Background

Tumor necrosis factor (TNF; see MIM 191160) receptor-associated factors, such as TRAF7, are signal transducers for members of the TNF receptor superfamily (see MIM 191190). TRAFs are composed of an N-terminal cysteine/histidine-rich region containing zinc RING and/or zinc finger motifs; a coiled-coil (leucine zipper) motif; and a homologous region that defines the TRAF family, the TRAF domain, which is involved in self-association and receptor binding.