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The antibody against TRIT1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 48-300 of human TRIT1 (NP_060116.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against TRIT1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 48-300 of human TRIT1 (NP_060116.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-03430A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TRIT1 |
| Target Synonyms | IPT; GRO1; IPPT; MOD5; hGRO1; IPTase; COXPD35; TRIT1 | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 48-300 of human TRIT1 (NP_060116.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9H3H1 | Immunogen Sequence |
Uniprot Id
Q9H3H1
Target Species
Human
Target Name
TRIT1
Target Full Name
tRNA dimethylallyltransferase
Target Function
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 of both cytosolic and mitochondrial tRNAs, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
Target Subcellular Location
[Isoform 1]: Mitochondrion.; [Isoform 4]: Mitochondrion.; [Isoform 2]: Cytoplasm.; [Isoform 3]: Cytoplasm.; [Isoform 5]: Cytoplasm.
Target Protein Families
IPP transferase family
Target Synonyms
2310075G14Rik; AI314189; AI314635; AV099619; FLJ20061; hGRO1; IPP transferase; IPPT; IPT; IPTase; Isopentenyl diphosphate:tRNA isopentenyltransferase; Isopentenyl-diphosphate:tRNA isopentenyltransferase; MGC149242; MGC149243; mitochondrial; MOD5; MOD5_HUMAN; OTTMUSP00000009314; Putative protein TR2IT1; RP23-121J14.6; TRIT 1; TRIT1; tRNA dimethylallyltransferase; tRNA isopentenylpyrophosphate transferase; tRNA isopentenyltransferase 1; tRNA isopentenyltransferase; tRNA isopentenyltransferase mitochondrial
Target Background
This gene encodes a protein that that is targeted to the mitochondrion and modifies transfer RNAs (tRNAs) by adding a dimethylallyl group onto the adenine at position 37. This modification is important for maintaining the correct reading frame during protein translation. This gene is considered a tumor suppressor and its expression can decrease cell growth. Alternative splicing results in multiple transcripts variants, most of which are likely non-functional.
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