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The antibody against UIMC1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 449-719 of human UIMC1 (NP_057374.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against UIMC1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 449-719 of human UIMC1 (NP_057374.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-00641A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | UIMC1 |
| Target Synonyms | RAP80; X2HRIP110; UIMC1 | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, 293T, DU145, Mouse thymus | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 449-719 of human UIMC1 (NP_057374.3). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q96RL1 | Immunogen Sequence |
Uniprot Id
Q96RL1
Target Species
Human
Target Name
UIMC1
Target Full Name
BRCA1-A complex subunit RAP80
Target Function
Ubiquitin-binding protein. Specifically recognizes and binds 'Lys-63'-linked ubiquitin. Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1.
Target Subcellular Location
Nucleus. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs).
Target Protein Families
RAP80 family
Target Tissue Specificity
Expressed in testis, ovary, thymus and heart. Expressed in germ cells of the testis.
Target Synonyms
BRCA1-A complex subunit RAP80; Nuclear zinc finger protein RAP80; OTTHUMP00000161441; OTTHUMP00000223372; OTTHUMP00000223374; RAP80; Receptor associated protein 80; Receptor-associated protein 80; Retinoid X receptor interacting protein 110; Retinoid x receptor interacting protein; Retinoid X receptor-interacting protein 110; RIP110; Rxrip110; Ubiquitin interaction motif containing 1; Ubiquitin interaction motif containing protein 1; Ubiquitin interaction motif-containing protein 1; UIMC1; UIMC1_HUMAN; X2HRIP110
Target Background
This gene encodes a nuclear protein that interacts with Brca1 (breast cancer 1) in a complex to recognize and repair DNA lesions. This protein binds ubiquitinated lysine 63 of histone H2A and H2AX. This protein may also function as a repressor of transcription. Alternative splicing results in multiple transcript variants.
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