Rabbit anti-Human UNC93B1 Polyclonal Antibody

The antibody against UNC93B1 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 450-550 of human UNC93B1 (NP_112192.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-10121A

Number

Cat.No	ADA-10121A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	UNC93B1
Target Synonyms	IIAE1; UNC93; UNC93B; Unc-93B1; UNC93B1	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.01% thimerosal, pH7.3.	Purification Method	Affinity purification
Positive Samples	HeLa, Mouse kidney, 293T, Mouse lung, Mouse spleen, Rat kidney, Rat lung, Rat spleen	Application	ELISA, WB

Cat.No

ADA-10121A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

UNC93B1

Target Synonyms

IIAE1; UNC93; UNC93B; Unc-93B1; UNC93B1

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.01% thimerosal, pH7.3.

Purification Method

Affinity purification

Positive Samples

HeLa, Mouse kidney, 293T, Mouse lung, Mouse spleen, Rat kidney, Rat lung, Rat spleen

Application

ELISA, WB

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 450-550 of human UNC93B1 (NP_112192.2).	Target Species	Human
Immunogen Sequence	KTGLSTLLGILYEDKERQDFIFTIYHWWQAVAIFTVYLGSSLHMKAKLAVLLVTLVAAAVSYLRMEQKLRRGVAPRQPRIPRPQHKVRGYRYLEEDNSDES	Uniprot ID	Q9H1C4

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 450-550 of human UNC93B1 (NP_112192.2).

Target Species

Human

Immunogen Sequence

KTGLSTLLGILYEDKERQDFIFTIYHWWQAVAIFTVYLGSSLHMKAKLAVLLVTLVAAAVSYLRMEQKLRRGVAPRQPRIPRPQHKVRGYRYLEEDNSDES

Uniprot ID

Q9H1C4

Background Information

Uniprot Id

Q9H1C4
Target Species

Human
Target Name

UNC93B1
Target Full Name

Protein unc-93 homolog B1
Target Function

Plays an important role in innate and adaptive immunity by regulating nucleotide-sensing Toll-like receptor (TLR) signaling. Required for the transport of a subset of TLRs (including TLR3, TLR7 and TLR9) from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. May play a role in autoreactive B-cells removal.
Target Involvement

Herpes simplex encephalitis 1 (HSE1)
Target Subcellular Location

Endoplasmic reticulum membrane; Multi-pass membrane protein. Endosome. Lysosome. Cytoplasmic vesicle, phagosome.
Target Protein Families

Unc-93 family
Target Tissue Specificity

Expressed in plasmocytoid dendritic cells (at protein level). Highly expressed in antigen-presenting cells. Expressed in heart, and at lower level in kidney. Expressed at low level in other tissues.
Target Synonyms

UNC93B1; UNC93; UNC93B; Protein unc-93 homolog B1; Unc-93B1; hUNC93B1
Target Background

This gene encodes a protein that is involved in innate and adaptive immune response by regulating toll-like receptor signaling. The encoded protein traffics nucleotide sensing toll-like receptors to the endolysosome from the endoplasmic reticulum. Deficiency of the encoded protein has been associated with herpes simplex encephalitis.

Rabbit anti-Human UNC93B1 Polyclonal Antibody

Specifications

Immunogen Information

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