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The antibody against USP30 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 57-390 of human USP30 (NP_116052.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against USP30 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 57-390 of human USP30 (NP_116052.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
| Cat.No | ADA-09554A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | USP30 |
| Target Synonyms | USP30 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse lung, Rat lung | Application | ELISA, WB, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 57-390 of human USP30 (NP_116052.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q70CQ3 | Immunogen Sequence |
Uniprot Id
Q70CQ3
Target Species
Human
Target Name
USP30
Target Full Name
Ubiquitin carboxyl-terminal hydrolase 30
Target Function
Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkin's ability to drive mitophagy. Preferentially cleaves 'Lys-6'- and 'Lys-11'-linked polyubiquitin chains, 2 types of linkage that participate in mitophagic signaling. Does not cleave efficiently polyubiquitin phosphorylated at 'Ser-65'. Acts as negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2.
Target Subcellular Location
Mitochondrion outer membrane.
Target Protein Families
Peptidase C19 family
Target Tissue Specificity
Expressed in skeletal muscle, pancreas, liver and kidney.
Target Synonyms
Deubiquitinating enzyme 30; FLJ40511; Ub-specific protease 30; Ubiquitin carboxyl terminal hydrolase 30; Ubiquitin carboxyl-terminal hydrolase 30; Ubiquitin specific peptidase 30; Ubiquitin specific processing protease 30; Ubiquitin thioesterase 30; Ubiquitin thiolesterase 30; Ubiquitin-specific-processing protease 30; UBP30_HUMAN; usp30
Target Background
USP30, a member of the ubiquitin-specific protease family (see USP1, MIM 603478), is a novel mitochondrial deubiquitinating (DUB) enzyme (Nakamura and Hirose, 2008 [PubMed 18287522]).
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