Rabbit anti-Human WNK3 Polyclonal Antibody

Uniprot Id

Q9BYP7

Target Species

Human

Target Name

WNK3

Target Full Name

Serine/threonine-protein kinase WNK3

Target Function

Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Phosphorylates WNK4. Regulates the phosphorylation of SLC12A1 and SLC12A2. Increases Ca(2+) influx mediated by TRPV5 and TRPV6 by enhancing their membrane expression level via a kinase-dependent pathway. Inhibits the activity of KCNJ1 by decreasing its expression at the cell membrane in a non-catalytic manner.; Isoform 1, isoform 2, isoform 3 and isoform 4 stimulate the activity of SLC12A1, SLC12A2 and SLC12A3 and inhibit the activity of SLC12A4, SLC12A5, SLC12A6 and SLC12A7. According to PubMed:19470686, isoform 1 inhibits the activity of SLC12A3.

Target Subcellular Location

Cytoplasm.

Target Protein Families

Protein kinase superfamily, Ser/Thr protein kinase family, WNK subfamily

Target Tissue Specificity

Expressed in brain, lung, kidney, liver and pancreas, and in fetal tissues including placenta, fetal brain, lung and kidney. Very low levels of expression were also detected in fetal heart, thymus, liver and spleen. Isoform 1 is brain-specific. Isoform 3

Target Synonyms

KIAA1566; PRKWNK 3; PRKWNK3; Protein kinase lysine deficient 3; Protein kinase lysine-deficient 3; Protein kinase with no lysine 3; Serine/threonine protein kinase WNK3; Serine/threonine-protein kinase WNK3; WNK 3; WNK lysine deficient protein kinase 3; Wnk3; WNK3_HUMAN

Target Background

This gene encodes a protein belonging to the 'with no lysine' family of serine-threonine protein kinases. These family members lack the catalytic lysine in subdomain II, and instead have a conserved lysine in subdomain I. This family member functions as a positive regulator of the transcellular Ca2+ transport pathway, and it plays a role in the increase of cell survival in a caspase-3-dependent pathway. Alternative splicing results in multiple transcript variants.