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The antibody against ZMYND8 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 959-1188 of human ZMYND8 (NP_898868.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against ZMYND8 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 959-1188 of human ZMYND8 (NP_898868.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-00010A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ZMYND8 |
| Target Synonyms | RACK7; PRKCBP1; PRO2893; ZMYND8 | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | A375, LO2, MCF-7, U-87 MG | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 959-1188 of human ZMYND8 (NP_898868.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9ULU4 | Immunogen Sequence |
Uniprot Id
Q9ULU4
Target Species
Human
Target Name
ZMYND8
Target Full Name
MYND-type zinc finger-containing chromatin reader ZMYND8
Target Function
May act as a transcriptional corepressor for KDM5D. Required for KDM5D-mediated down-regulation of diverse metastasis-associated genes; the function seems to involve the recognition of the dual histone signature H3K4me1-H3K14ac. Suppresses prostate cancer cell invasion.
Target Subcellular Location
Nucleus. Cytoplasm.
Target Tissue Specificity
Expressed in all tissues examined with highest expression in brain, lung, pancreas, and placenta. Expressed in cutaneous T-cell lymphomas (CTCL).
Target Synonyms
ZMYND8; KIAA1125; PRKCBP1; RACK7; Protein kinase C-binding protein 1; Cutaneous T-cell lymphoma-associated antigen se14-3; CTCL-associated antigen se14-3; Rack7; Zinc finger MYND domain-containing protein 8
Target Background
The protein encoded by this gene is a receptor for activated C-kinase (RACK) protein. The encoded protein has been shown to bind in vitro to activated protein kinase C beta I. In addition, this protein is a cutaneous T-cell lymphoma-associated antigen. Finally, the protein contains a bromodomain and two zinc fingers, and is thought to be a transcriptional regulator. Multiple transcript variants encoding several different isoforms have been found for this gene.
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