KLK3 Recombinant Monoclonal Antibody

Uniprot Id

P07288

Target Species

Human

Target Name

KLK3

Target Full Name

Prostate-specific antigen

Target Function

Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum.

Target Subcellular Location

Secreted.

Target Protein Families

Peptidase S1 family, Kallikrein subfamily

Target Synonyms

APS; PSA; hK3; KLK2A1; KLK3

Target Background

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. The gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. It encodes a single-chain glycoprotein, a protease which is synthesized in the epithelial cells of the prostate gland, and is present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. The serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms.