Recombinant Human 28S ribosomal protein S16, mitochondrial (MRPS16)

Uniprot Id

Q9Y3D3

Target Species

Human

Target Name

MRPS16

Target Full Name

Small ribosomal subunit protein bS16m

Target Involvement

Combined oxidative phosphorylation deficiency 2 (COXPD2)

Target Subcellular Location

Mitochondrion.

Target Protein Families

Bacterial ribosomal protein bS16 family

Target Research Area

Epigenetics and Nuclear Signaling

Target Synonyms

28S ribosomal protein S16; 28S ribosomal protein S16 mitochondrial; CGI-132; COXPD2; mitochondrial; Mitochondrial ribosomal protein S16; MRP-S16; mrps16; RPMS16; RT16_HUMAN; S16mt

Target Background

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S16P family. The encoded protein is one of the most highly conserved ribosomal proteins between mammalian and yeast mitochondria. Three pseudogenes (located at 8q21.3, 20q13.32, 22q12-q13.1) for this gene have been described.