Recombinant Human 28S ribosomal protein S2, mitochondrial (MRPS2)

Uniprot Id

Q9Y399

Target Species

Human

Target Name

MRPS2

Target Full Name

Small ribosomal subunit protein uS2m

Target Function

Required for mitoribosome formation and stability, and mitochondrial translation.

Target Subcellular Location

Mitochondrion.

Target Protein Families

Universal ribosomal protein uS2 family

Target Synonyms

28S ribosomal protein S2; 28S ribosomal protein S2 mitochondrial; CGI 91; CGI91; Mitochondrial 28S ribosomal protein S2; mitochondrial; Mitochondrial ribosomal protein S2; MRP S2; MRP-S2; MRPS2; OTTHUMP00000022545; OTTHUMP00000022546; RT02_HUMAN; S2mt

Target Background

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S2 family. Alternatively spliced transcript variants have been observed for this gene.