Recombinant Human 39S ribosomal protein L12, mitochondrial (MRPL12)

Uniprot Id

P52815

Target Species

Human

Target Name

MRPL12

Target Full Name

Large ribosomal subunit protein bL12m

Target Function

As a component of the mitochondrial large ribosomal subunit, it plays a role in mitochondrial translation. Associates with mitochondrial RNA polymerase to activate transcription.

Target Subcellular Location

Mitochondrion.

Target Protein Families

Bacterial ribosomal protein bL12 family

Target Research Area

Tags & Cell Markers

Target Synonyms

39S ribosomal protein L12; 39S ribosomal protein L12, mitochondrial; 5c5-2; FLJ60124; L12mt; MGC8610; mitochondrial; Mitochondrial ribosomal protein L12; MRP-L12; MRP-L31/34; MRPL12; MRPL7; MRPL7/L12; RM12_HUMAN; RPML12

Target Background

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein which forms homodimers. In prokaryotic ribosomes, two L7/L12 dimers and one L10 protein form the L8 protein complex.