Recombinant Human 39S ribosomal protein L30, mitochondrial (MRPL30)

Uniprot Id

Q8TCC3

Target Species

Human

Target Name

MRPL30

Target Full Name

Large ribosomal subunit protein uL30m

Target Subcellular Location

Mitochondrion.

Target Protein Families

Universal ribosomal protein uL30 family

Target Synonyms

MRPL30; MRPL28; RPML28; HSPC249; 39S ribosomal protein L30; mitochondrial; L30mt; MRP-L30; 39S ribosomal protein L28; mitochondrial; L28mt; MRP-L28; Mitochondrial large ribosomal subunit protein uL30m

Target Background

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Alternative splicing results in multiple transcript variants. Pseudogenes corresponding to this gene are found on chromosomes 6p and 12p. Read-through transcription also exists between this gene and the neighboring upstream lipoyltransferase 1 (LIPT1) gene.