Recombinant Human 39S ribosomal protein L45, mitochondrial (MRPL45), Truncated

Uniprot Id

Q9BRJ2

Target Species

Human

Target Name

MRPL45

Target Full Name

Large ribosomal subunit protein mL45

Target Subcellular Location

Mitochondrion.

Target Protein Families

Mitochondrion-specific ribosomal protein mL45 family

Target Synonyms

39S ribosomal protein L45; 39S ribosomal protein L45 mitochondrial; L45mt; MGC11321; mitochondrial; Mitochondrial ribosomal protein L45; MRP L45; MRP-L45; MRPL45; RM45_HUMAN

Target Background

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Alternative splicing results in multiple transcript variants. Pseudogenes corresponding to this gene are found on chromosomes 2p and 17q.