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| Cat.No | ACP15080 | Target Name | XRN1 |
|---|---|---|---|
| Target Synonyms | XRN1; SEP1; 5'-3' exoribonuclease 1; EC 3.1.13.-; Strand-exchange protein 1 homolog | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q8IZH2 |
|---|
Uniprot Id
Q8IZH2
Target Species
Human
Target Name
XRN1
Target Full Name
5'-3' exoribonuclease 1
Target Function
Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA. Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS).
Target Subcellular Location
Cytoplasm. Note=Discrete foci at the inner surface of the cell membrane.
Target Protein Families
5'-3' exonuclease family
Target Tissue Specificity
Expressed in heart, brain, pancreas, spleen, testis, osteogenic sarcoma (OGS) biopsy and primary cell lines.
Target Synonyms
XRN1; SEP1; 5'-3' exoribonuclease 1; EC 3.1.13.-; Strand-exchange protein 1 homolog
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