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The expression region of this recombinant Human ADAMTS14 covers amino acids 253-555. The calculated molecular weight for this ADAMTS14 protein is 40.2 kDa. This protein is generated in a e.coli-based system. The ADAMTS14 coding gene included the N-terminal 6xHis tag, which simplifies the detection and purification processes of the recombinant ADAMTS14 protein in following stages of expression and purification.The human A disintegrin and metalloproteinase with thrombospondin motifs 14 (ADAMTS14) is a member of the ADAMTS family of proteases, playing a crucial role in extracellular matrix (ECM) modulation. ADAMTS14 is involved in the cleavage of aggrecan, a major proteoglycan in the ECM of cartilage, contributing to tissue remodeling. This protease is implicated in various physiological and pathological processes, including development, inflammation, and arthritis. By cleaving ECM components, ADAMTS14 influences cell-matrix interactions and tissue homeostasis. Moreover, dysregulation of ADAMTS14 has been linked to certain diseases, highlighting its potential as a therapeutic target.
The expression region of this recombinant Human ADAMTS14 covers amino acids 253-555. The calculated molecular weight for this ADAMTS14 protein is 40.2 kDa. This protein is generated in a e.coli-based system. The ADAMTS14 coding gene included the N-terminal 6xHis tag, which simplifies the detection and purification processes of the recombinant ADAMTS14 protein in following stages of expression and purification.The human A disintegrin and metalloproteinase with thrombospondin motifs 14 (ADAMTS14) is a member of the ADAMTS family of proteases, playing a crucial role in extracellular matrix (ECM) modulation. ADAMTS14 is involved in the cleavage of aggrecan, a major proteoglycan in the ECM of cartilage, contributing to tissue remodeling. This protease is implicated in various physiological and pathological processes, including development, inflammation, and arthritis. By cleaving ECM components, ADAMTS14 influences cell-matrix interactions and tissue homeostasis. Moreover, dysregulation of ADAMTS14 has been linked to certain diseases, highlighting its potential as a therapeutic target.
| Cat.No | ACP01208 | Target Name | ADAMTS14 |
|---|---|---|---|
| Target Synonyms | (ADAM-TS 14)(ADAM-TS14)(ADAMTS-14) | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 253-555aa |
| Mol Weight | 40.2 kDa | Protein Length | Partial |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q8WXS8 |
|---|
Uniprot Id
Q8WXS8
Target Species
Human
Target Name
ADAMTS14
Target Full Name
A disintegrin and metalloproteinase with thrombospondin motifs 14
Target Function
Has aminoprocollagen type I processing activity in the absence of ADAMTS2. Seems to be synthesized as a latent enzyme that requires activation to display aminoprocollagen peptidase activity. Cleaves lysyl oxidase LOX at a site downstream of its propeptide cleavage site to produce a short LOX form.
Target Subcellular Location
Secreted, extracellular space, extracellular matrix.
Target Tissue Specificity
Expressed in retina and at low levels in brain, lung and placenta. High expression in fetal tissues.
Target Research Area
Others
Target Synonyms
ADAMTS14A disintegrin and metalloproteinase with thrombospondin motifs 14; ADAM-TS 14; ADAM-TS14; ADAMTS-14; EC 3.4.24.-
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