Recombinant Human Alanine aminotransferase 1 (GPT)

Uniprot Id

P24298

Target Species

Human

Target Name

GPT

Target Full Name

Alanine aminotransferase 1

Target Function

Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles.

Target Subcellular Location

Cytoplasm.

Target Protein Families

Class-I pyridoxal-phosphate-dependent aminotransferase family, Alanine aminotransferase subfamily

Target Tissue Specificity

Liver, kidney, heart, and skeletal muscles. Expressed at moderate levels in the adipose tissue.

Target Research Area

Signal Transduction, Metabolism

Target Synonyms

AAT1; Alanine aminotransferase 1; Alanine aminotransferase; ALAT1_HUMAN; ALT1; Glutamate pyruvate transaminase 1; Glutamic alanine transaminase 1; Glutamic pyruvate transaminase (alanine aminotransferase); Glutamic pyruvic transaminase 1; Glutamic--alanine transaminase 1; Glutamic--pyruvic transaminase 1; GPT 1; gpt; GPT1

Target Background

This gene encodes cytosolic alanine aminotransaminase 1 (ALT1); also known as glutamate-pyruvate transaminase 1. This enzyme catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate and, therefore, plays a key role in the intermediary metabolism of glucose and amino acids. Serum activity levels of this enzyme are routinely used as a biomarker of liver injury caused by drug toxicity, infection, alcohol, and steatosis. A related gene on chromosome 16 encodes a putative mitochondrial alanine aminotransaminase.