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| Cat.No | ACP11933 | Target Name | SLF1 |
|---|---|---|---|
| Target Synonyms | SLF1; ANKRD32; BRCTD1; SMC5-SMC6 complex localization factor protein 1; Ankyrin repeat domain-containing protein 32; BRCT domain-containing protein 1; Smc5/6 localization factor 1 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9BQI6 |
|---|
Uniprot Id
Q9BQI6
Target Species
Human
Target Name
SLF1
Target Full Name
SMC5-SMC6 complex localization factor protein 1
Target Function
Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance. The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks. Promotes the recruitment of SLF2 and the SMC5-SMC6 complex to DNA lesions.
Target Subcellular Location
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Target Synonyms
SLF1; ANKRD32; BRCTD1; SMC5-SMC6 complex localization factor protein 1; Ankyrin repeat domain-containing protein 32; BRCT domain-containing protein 1; Smc5/6 localization factor 1
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