Recombinant Human Anthrax toxin receptor 1 (ANTXR1), Truncated

Uniprot Id

Q9H6X2

Target Species

Human

Target Name

ANTXR1

Target Full Name

Anthrax toxin receptor 1

Target Function

Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells.; (Microbial infection) Acts as a receptor for protective antigen (PA) of B.anthracis.

Target Involvement

Hemangioma, capillary infantile (HCI); GAPO syndrome (GAPO)

Target Subcellular Location

Cell membrane; Single-pass type I membrane protein. Cell projection, lamellipodium membrane; Single-pass type I membrane protein. Cell projection, filopodium membrane; Single-pass type I membrane protein.

Target Protein Families

ATR family

Target Tissue Specificity

Detected in umbilical vein endothelial cells (at protein level). Highly expressed in tumor endothelial cells.

Target Research Area

Tags & Cell Markers

Target Synonyms

Anthrax toxin receptor 1; ANTR1_HUMAN; Antxr1; ATR; Tumor endothelial marker 8

Target Background

This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described.