Recombinant Human AP-3 complex subunit sigma-1 (AP3S1)

Uniprot Id

Q92572

Target Species

Human

Target Name

AP3S1

Target Full Name

AP-3 complex subunit sigma-1

Target Function

Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.

Target Subcellular Location

Golgi apparatus. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.

Target Protein Families

Adaptor complexes small subunit family

Target Tissue Specificity

Present in all adult tissues examined.

Target Synonyms

Adapter-related protein complex 3 sigma-1 subunit; Adaptor-related protein complex 3; AP-3 complex sigma-3A subunit; AP-3 complex subunit sigma-1; AP-3 complex subunit sigma-3A; AP3S1; AP3S1_HUMAN; CLAPS3; Clathrin associated/assembly/adapter protein small 3; Clathrin-associated/assembly/adapter protein; Sigma-3A-adaptin; Sigma-adaptin 3a; Sigma3A; Sigma3A-adaptin; small 3