Recombinant Human Apoptosis regulatory protein Siva (SIVA1)

Uniprot Id

O15304

Target Species

Human

Target Name

SIVA1

Target Full Name

Apoptosis regulatory protein Siva

Target Function

Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.

Target Subcellular Location

Cytoplasm. Nucleus. Note=In the nucleus, accumulates in dot-like structures.

Target Tissue Specificity

Ubiquitous. Mostly expressed in thymus, testis, ovary, prostate, small intestine and spleen and less in colon.

Target Research Area

Cell Biology

Target Synonyms

Apoptosis regulatory protein Siva; CD27 binding (Siva) protein; CD27-binding protein; CD27BP; Siva 1 ; Siva 2; SIVA_HUMAN; Siva1

Target Background

This gene encodes an E3 ubiquitin ligase that regulates cell cycle progression, cell proliferation and apoptosis. The N-terminus of this protein binds to the cytoplasmic tail of the CD27 antigen, a member of the tumor necrosis factor receptor (TNFR) superfamily. In response to UV radiation-induced DNA damage, this protein has been shown to mediate the ubiquitination of proliferating cell nuclear antigen (PCNA), an important step in translesion DNA synthesis.