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| Cat.No | ACP10294 | Target Name | ADAP2 |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Expression Range | 1-381 | Protein Length | Full length protein |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9NPF8 |
|---|
Uniprot Id
Q9NPF8
Target Species
Human
Target Name
ADAP2
Target Full Name
Arf-GAP with dual PH domain-containing protein 2
Target Function
GTPase-activating protein for the ADP ribosylation factor family (Potential). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). Possesses a stoichiometry of two binding sites for InsP4 with identical affinity.
Target Subcellular Location
Cytoplasm. Cell membrane. Note=Constitutively associated with the plasma membrane. Excluded from the nucleus.
Target Tissue Specificity
Highly expressed in placenta, spleen, kidney, skeletal muscle and adrenal gland. Weakly expressed in thyroid, liver, heart, lung, small intestine, peripheral blood leukocytes. Not detected in spinal cord, brain, stomach, trachea, colon, lymph node and bon
Target Synonyms
Adap2; ADAP2_HUMAN; Arf-GAP with dual PH domain-containing protein 2; ArfGAP with dual PH domains 2; cent b; Centa 2; CENTA2; Centaurin alpha 2; Centaurin alpha 2 protein; Centaurin beta; Centaurin-alpha-2; Cnt-a2; HSA272195
Target Background
The protein encoded by this gene binds beta-tubulin and increases the stability of microtubules. The encoded protein can also translocate to the cell membrane and bind phosphatidylinositol 3, 4, 5-trisphosphate (PtdInsP3) and inositol 1, 3, 4, 5-tetrakisphosphate (InsP4). In addition, this protein is a GTPase-activating protein for ADP ribosylation factor 6 and may be able to block the entry of some RNA viruses.
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