Recombinant Human ATP-binding cassette sub-family A member 8 (ABCA8), Truncated

Uniprot Id

O94911

Target Species

Human

Target Name

ABCA8

Target Full Name

ABC-type organic anion transporter ABCA8

Target Function

Catalyzes ATP-dependent import of organic anions such as taurocholate and estrone sulfate. In vitro, also imports ochratoxin A. Also mediates cholesterol efflux independent of apolipoprotein, and plays a role in sphingomyelin production in oligodendrocytes.; Catalyzes ATP-dependent efflux of cholesterol and taurocholate. Interaction with ABCA1 potentiates cholesterol efflux to lipid-free APOA1, which regulates high-density lipoprotein cholesterol levels.

Target Subcellular Location

Cell membrane; Multi-pass membrane protein. Basolateral cell membrane.

Target Protein Families

ABC transporter superfamily, ABCA family

Target Tissue Specificity

Widely expressed with higher expression in heart, skeletal muscle and liver. Highly expressed in the superior frontal white matter and inferior temporal white matter.

Target Synonyms

ABCA8; KIAA0822ATP-binding cassette sub-family A member 8

Target Background

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. The encoded protein may regulate lipid metabolism and be involved in the formation and maintenance of myelin. Alternative splicing results in multiple transcript variants.