Recombinant Human ATP-dependent RNA helicase DHX8 (DHX8), Truncated

Uniprot Id

Q14562

Target Species

Human

Target Name

DHX8

Target Full Name

ATP-dependent RNA helicase DHX8

Target Function

Involved in pre-mRNA splicing as component of the spliceosome. Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome.

Target Subcellular Location

Nucleus.

Target Protein Families

DEAD box helicase family, DEAH subfamily, DDX8/PRP22 sub-subfamily

Target Tissue Specificity

Expressed in skin, cervix and nerve. Also expressed in the brain.

Target Synonyms

ATP dependent RNA helicase DHX8; ATP-dependent RNA helicase dhx8; DDX 8; DDX8; DEAD/H (Asp Glu Ala Asp/His) box polypeptide 8 (RNA helicase); DEAD/H (Asp Glu Ala Asp/His) box polypeptide 8; DEAD/H box 8; DEAD/H box polypeptide 8; DEAH (Asp Glu Ala His) box polypeptide 8; DEAH box polypeptide 8; DEAH box protein 8; DHX 8; dhx8; DHX8_HUMAN; HRH 1; HRH1; PRP 22; PRP22; PRP22; S. cerevisiae; homolog of; PRPF 22; PRPF22; RNA helicase HRH 1; RNA helicase HRH1

Target Background

This gene is a member of the DEAH box polypeptide family. The encoded protein contains the DEAH (Asp-Glu-Ala-His) motif which is characteristic of all DEAH box proteins, and is thought to function as an ATP-dependent RNA helicase that regulates the release of spliced mRNAs from spliceosomes prior to their export from the nucleus. This protein may be required for the replication of human immunodeficiency virus type 1 (HIV-1). Alternative splicing results in multiple transcript variants.