Recombinant Human Basic leucine zipper transcriptional factor ATF-like 2 (BATF2)

Uniprot Id

Q8N1L9

Target Species

Human

Target Name

BATF2

Target Full Name

Basic leucine zipper transcriptional factor ATF-like 2

Target Function

AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system. Following infection, participates in the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes. Selectively suppresses CCN1 transcription and hence blocks the downstream cell proliferation signals produced by CCN1 and inhibits CCN1-induced anchorage-independent growth and invasion in several cancer types, such as breast cancer, malignant glioma and metastatic melanoma. Possibly acts by interfering with AP-1 binding to CCN1 promoter.

Target Subcellular Location

Nucleus.

Target Protein Families

BZIP family

Target Synonyms

BATF2Basic leucine zipper transcriptional factor ATF-like 2; B-ATF-2; Suppressor of AP-1 regulated by IFN; SARI