Recombinant Human Beta-1,4-galactosyltransferase 3 (B4GALT3), Truncated

Uniprot Id

O60512

Target Species

Human

Target Name

B4GALT3

Target Full Name

Beta-1,4-galactosyltransferase 3

Target Function

Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

Target Subcellular Location

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Trans cisternae of Golgi stack.

Target Protein Families

Glycosyltransferase 7 family

Target Tissue Specificity

Found in various tissues. Highest expression in placenta, prostate, testis, ovary, intestine and muscle, and in fetal brain.

Target Research Area

Metabolism

Target Synonyms

4-galactosyltransferase 3; 4-galactosyltransferase; 4-GalTase 3; b4Gal T3; b4Gal-T3; B4GALT3; B4GT3_HUMAN; Beta 1,4 galactosyltransferase 3 ; Beta 1,4 GalTase 3; Beta-1; Beta-N-acetylglucosaminyl-glycolipid beta-1; Beta4Gal T3; Beta4Gal-T3; Nal synthase; UDP Gal:beta GlcNAc beta-1,4 galactosyltransferase 3; UDP-Gal:beta-GlcNAc beta-1; UDP-galactose:beta-N-acetylglucosamine beta-1

Target Background

This gene is one of seven beta-1, 4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1, 4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. This gene encodes an enzyme that may be mainly involved in the synthesis of the first N-acetyllactosamine unit of poly-N-acetyllactosamine chains. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.