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Recombinant Human Beta,beta-carotene 9′,10′-oxygenase (BCO2)

ACP11323

Number
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High Purity LevelsPrecision and ReliabilityCustomization Options

Specifications


Cat.No ACP11323 Target NameBCO2
Target Synonyms10'-oxygenase; Beta-carotene dioxygenase 2, B-diox-II; BCDO2_HUMAN; Bco2; Beta, beta-carotene 9'FormLyophilized powder
Expression SystemCustom Production. Please inquire and provide the desire expression system.Expression Range1-579
Protein LengthFull length proteinPurity>85% (SDS-PAGE)
Storage Buffer5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information


Target SpeciesHumanUniprot IDQ9BYV7
Background Information
  • Uniprot Id

    Q9BYV7

  • Target Species

    Human

  • Target Name

    BCO2

  • Target Full Name

    Carotenoid-cleaving dioxygenase, mitochondrial

  • Target Function

    Asymmetrically cleaves beta-carotene at the 9',10' double bond resulting in the formation of beta-apo-10'-carotenal and beta-ionone. Besides beta-carotene, lycopene is also oxidatively cleaved. The apocarotenals formed by this enzyme may be the precursors for the biosynthesis of retinoic acid or exert unknown physiological effects.

  • Target Subcellular Location

    Mitochondrion.

  • Target Protein Families

    Carotenoid oxygenase family

  • Target Tissue Specificity

    Highly expressed in retinal pigment epithelium. Also expressed in stomach, small intestine, liver, testis, kidney, adrenal gland, pancreas, heart, skeletal muscle and prostate (at protein level).

  • Target Synonyms

    B-diox-II; BCDO2_HUMAN; Bco2; Beta,beta-carotene 9',10'-oxygenase; Beta-carotene dioxygenase 2

  • Target Background

    This gene encodes an enzyme which oxidizes carotenoids such as beta-carotene during the biosynthesis of vitamin A. Multiple transcript variants encoding different isoforms have been found for this gene.

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