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The region for expressing recombinant Human BMP3 contains amino acids 363-472. The expected molecular weight for the BMP3 protein is calculated to be 16.4 kDa. This BMP3 recombinant protein is manufactured in e.coli. The N-terminal 6xHis tag was fused into the coding gene segment of BMP3, making it easier to detect and purify the BMP3 recombinant protein in the later stages of expression and purification.Bone Morphogenetic Protein 3 (BMP3) is a protein that has garnered significant attention in biomedical research. One of its primary areas of study is in the field of osteobiology, where BMP3 plays a crucial regulatory role in bone development and maintenance. Research indicates that BMP3 is involved in physiological and pathological processes such as osteoblast differentiation, bone formation, and osteoporosis. The functional mechanisms of BMP3 in aspects like bone fracture repair and metabolic disorders have sparked widespread interest among scientists. Additionally, BMP3's exploration extends to areas such as muscle biology and joint diseases. In muscle growth and repair, BMP3 also plays a certain role. Abnormal expression of BMP3 is associated with diseases like arthritis, making it a focus of research in understanding its specific role in joint health.
The region for expressing recombinant Human BMP3 contains amino acids 363-472. The expected molecular weight for the BMP3 protein is calculated to be 16.4 kDa. This BMP3 recombinant protein is manufactured in e.coli. The N-terminal 6xHis tag was fused into the coding gene segment of BMP3, making it easier to detect and purify the BMP3 recombinant protein in the later stages of expression and purification.Bone Morphogenetic Protein 3 (BMP3) is a protein that has garnered significant attention in biomedical research. One of its primary areas of study is in the field of osteobiology, where BMP3 plays a crucial regulatory role in bone development and maintenance. Research indicates that BMP3 is involved in physiological and pathological processes such as osteoblast differentiation, bone formation, and osteoporosis. The functional mechanisms of BMP3 in aspects like bone fracture repair and metabolic disorders have sparked widespread interest among scientists. Additionally, BMP3’s exploration extends to areas such as muscle biology and joint diseases. In muscle growth and repair, BMP3 also plays a certain role. Abnormal expression of BMP3 is associated with diseases like arthritis, making it a focus of research in understanding its specific role in joint health.
| Cat.No | ACP04302 | Target Name | BMP3 |
|---|---|---|---|
| Target Synonyms | BMP-3; BMP-3A; bmp3; BMP3_HUMAN; BMP3A; Bone morphogenetic protein 3 (osteogenic); Bone morphogenetic protein 3; Bone morphogenetic protein 3A; Osteogenin | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 363-472aa |
| Mol Weight | 16.4kDa | Protein Length | Full Length of Mature Protein |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P12645 |
|---|
Uniprot Id
P12645
Target Species
Human
Target Name
BMP3
Target Full Name
Bone morphogenetic protein 3
Target Function
Growth factor of the TGF-beta superfamily that plays an essential role in developmental process by inducing and patterning early skeletal formation and by negatively regulating bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification. Initiates signaling cascades by associating with type II receptor ACVR2B to activate SMAD2-dependent and SMAD-independent signaling cascades including TAK1 and JNK pathways.
Target Subcellular Location
Secreted.
Target Protein Families
TGF-beta family
Target Tissue Specificity
Expressed in adult and fetal cartilage.
Target Research Area
Developmental Biology
Target Synonyms
BMP-3; BMP-3A; bmp3; BMP3_HUMAN; BMP3A; Bone morphogenetic protein 3 (osteogenic); Bone morphogenetic protein 3; Bone morphogenetic protein 3A; Osteogenin
Target Background
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein suppresses osteoblast differentiation, and negatively regulates bone density, by modulating TGF-beta receptor availability to other ligands.
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