Recombinant Human Butyrophilin-like protein 2 (BTNL2)

Uniprot Id

Q9UIR0

Target Species

Human

Target Name

BTNL2

Target Full Name

Butyrophilin-like protein 2

Target Function

Negative regulator of T-cell proliferation.

Target Involvement

Sarcoidosis 2 (SS2)

Target Subcellular Location

Membrane; Single-pass type II membrane protein. Note=Isoform 2 is present in the nuclear, vesicle and plasma membranes, isoform 3 is found in cytoplasmic vesicle structures and is not membrane bound.

Target Protein Families

Immunoglobulin superfamily, BTN/MOG family

Target Tissue Specificity

Expressed in brain, heart, kidney, liver, pancreas, ovary, leukocyte, small intestine, testis and thymus.

Target Research Area

Immunology

Target Synonyms

BTNL2Butyrophilin-like protein 2; BTL-II

Target Background

This gene encodes a major histocompatibility complex, class II associated, type I transmembrane protein which belongs to the butyrophilin-like B7 family of immunoregulators. It is thought to be involved in immune surveillance, serving as a negative T-cell regulator by decreasing T-cell proliferation and cytokine release. The encoded protein contains an N-terminal signal peptide, two pairs of immunoglobulin-like domains, separated by a heptad peptide sequence, and a C-terminal transmembrane domain. Naturally occurring mutations in this gene are associated with sarcoidosis, rheumatoid arthritis, ulcerative colitis, inflammatory bowel disease, myositis, type 1 diabetes, systemic lupus erythematosus, acute coronary syndrome, and prostate cancer.