Recombinant Human Butyrophilin subfamily 3 member A1 (BTN3A1), Truncated

Uniprot Id

O00481

Target Species

Human

Target Name

BTN3A1

Target Full Name

Butyrophilin subfamily 3 member A1

Target Function

Plays a role in T-cell activation and in the adaptive immune response. Regulates the proliferation of activated T-cells. Regulates the release of cytokines and IFNG by activated T-cells. Mediates the response of T-cells toward infected and transformed cells that are characterized by high levels of phosphorylated metabolites, such as isopentenyl pyrophosphate.

Target Subcellular Location

Cell membrane; Single-pass type I membrane protein.

Target Protein Families

Immunoglobulin superfamily, BTN/MOG family

Target Tissue Specificity

Detected on T-cells, natural killer cells, dendritic cells and macrophages (at protein level). Ubiquitous. Highly expressed in heart, pancreas and lung, Moderately expressed in placenta, liver and muscle.

Target Research Area

Immunology

Target Synonyms

BT3A1_HUMAN; BTN3A1; Butyrophilin subfamily 3 member A1; CD277

Target Background

The butyrophilin (BTN) genes are a group of major histocompatibility complex (MHC)-associated genes that encode type I membrane proteins with 2 extracellular immunoglobulin (Ig) domains and an intracellular B30.2 (PRYSPRY) domain. Three subfamilies of human BTN genes are located in the MHC class I region: the single-copy BTN1A1 gene (MIM 601610) and the BTN2 (e.g., BTN2A1; MIM 613590) and BTN3 (e.g., BNT3A1) genes, which have undergone tandem duplication, resulting in 3 copies of each (summary by Smith et al., 2010 [PubMed 20208008]).