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The region for expressing recombinant Human CXCR2 contains amino acids 1-40. The calculated molecular weight for this CXCR2 protein is 20.6 kDa. This CXCR2 recombinant protein is manufactured in e.coli. The CXCR2 gene fragment has been modified by fusing the N-terminal 6xHis-SUMO tag, providing convenience in detecting and purifying the recombinant CXCR2 protein during the following stages.Human C-X-C chemokine receptor type 2 (CXCR2) is a GPCR that plays a crucial role in immune responses and inflammation. Primarily expressed on the surface of various immune cells, including neutrophils, CXCR2 interacts with chemokines such as IL-8, to mediate cell migration and activation. This receptor is involved in directing immune cells to sites of infection or tissue damage. Beyond its role in immune function, CXCR2 has been implicated in various pathological conditions, including inflammatory diseases and cancer. Research on CXCR2 contributes to understanding immune system regulation and provides insights into potential therapeutic strategies for inflammatory disorders and cancer treatments.
The region for expressing recombinant Human CXCR2 contains amino acids 1-40. The calculated molecular weight for this CXCR2 protein is 20.6 kDa. This CXCR2 recombinant protein is manufactured in e.coli. The CXCR2 gene fragment has been modified by fusing the N-terminal 6xHis-SUMO tag, providing convenience in detecting and purifying the recombinant CXCR2 protein during the following stages.Human C-X-C chemokine receptor type 2 (CXCR2) is a GPCR that plays a crucial role in immune responses and inflammation. Primarily expressed on the surface of various immune cells, including neutrophils, CXCR2 interacts with chemokines such as IL-8, to mediate cell migration and activation. This receptor is involved in directing immune cells to sites of infection or tissue damage. Beyond its role in immune function, CXCR2 has been implicated in various pathological conditions, including inflammatory diseases and cancer. Research on CXCR2 contributes to understanding immune system regulation and provides insights into potential therapeutic strategies for inflammatory disorders and cancer treatments.
| Cat.No | ACP03768 | Target Name | CXCR2 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 1-40aa | Mol Weight | 20.6kDa |
| Protein Length | Partial | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P25025 |
|---|
Uniprot Id
P25025
Target Species
Human
Target Name
CXCR2
Target Full Name
C-X-C chemokine receptor type 2
Target Function
Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.
Target Subcellular Location
Cell membrane; Multi-pass membrane protein.
Target Protein Families
G-protein coupled receptor 1 family
Target Research Area
Signal Transduction
Target Synonyms
C-X-C chemokine receptor type 2; CD 182; CD182; CD182 antigen; CDw128b; Chemokine (CXC) receptor 2; CMKAR2; CXC-R2; CXCR 2; CXCR-2; CXCR2; CXCR2_HUMAN; GRO/MGSA receptor; High affinity interleukin-8 receptor B; IL 8 receptor type 2; IL 8R B; IL-8 receptor type 2; IL-8R B; IL8 RB; IL8 receptor type 2; IL8R B; IL8R2; IL8RA; Interleukin 8 Receptor B; Interleukin 8 receptor; beta; Interleukin 8 receptor; type 2
Target Background
The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified.
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