Recombinant Human Cadherin EGF LAG seven-pass G-type receptor 2 (CELSR2), Truncated

Uniprot Id

Q9HCU4

Target Species

Human

Target Name

CELSR2

Target Full Name

Cadherin EGF LAG seven-pass G-type receptor 2

Target Function

Receptor that may have an important role in cell/cell signaling during nervous system formation.

Target Subcellular Location

Cell membrane; Multi-pass membrane protein.

Target Protein Families

G-protein coupled receptor 2 family, LN-TM7 subfamily

Target Tissue Specificity

Highest expression in brain and testis.

Target Synonyms

Cadherin EGF LAG seven pass G type receptor 2 flamingo Drosophila homolog ; Cadherin EGF LAG seven-pass G-type receptor 2; Cadherin family member 10; CDHF10; CELR2_HUMAN; Celsr2; EGF like domain multiple 2; EGF-like protein 2; EGFL2; epidermal growth factor like 2; Epidermal growth factor-like protein 2; Flamingo homolog 3; Flamingo1; KIAA0279; MEGF3; Multiple EGF-like domains protein 3; Multiple epidermal growth factor-like domains 3; Multiple epidermal growth factor-like domains protein 3

Target Background

The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined.