Recombinant Human Calcium release-activated calcium channel protein 1 (ORAI1), Truncated

Uniprot Id

Q96D31

Target Species

Human

Target Name

ORAI1

Target Full Name

Calcium release-activated calcium channel protein 1

Target Function

Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores and channel activation by the Ca(2+) sensor, STIM1. CRAC channels are the main pathway for Ca(2+) influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT. Plays a prominent role in Ca(2+) influx at the basolateral membrane of mammary epithelial cells independently of the Ca(2+) content of endoplasmic reticulum or Golgi stores. May mediate transepithelial transport of large quantities of Ca(2+) for milk secretion.

Target Involvement

Immunodeficiency 9 (IMD9); Myopathy, tubular aggregate, 2 (TAM2)

Target Subcellular Location

Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein.

Target Protein Families

Orai family

Target Tissue Specificity

Expressed in naive CD4 and CD8 T cells (at protein level). Expressed at similar levels in naive and effector T helper cells.

Target Synonyms

ORAI1; CRACM1; TMEM142A; Calcium release-activated calcium channel protein 1; Protein orai-1; Transmembrane protein 142A

Target Background

The protein encoded by this gene is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. This type of channel is the primary way for calcium influx into T-cells. Defects in this gene are a cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1).