Recombinant Human Calcium signal-modulating cyclophilin ligand (CAMLG), Truncated

Uniprot Id

P49069

Target Species

Human

Target Name

CAMLG

Target Full Name

Guided entry of tail-anchored proteins factor CAMLG

Target Function

Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1/WRB, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. Required for the stability of GET1. Stimulates calcium signaling in T cells through its involvement in elevation of intracellular calcium. Essential for the survival of peripheral follicular B cells.

Target Subcellular Location

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Target Tissue Specificity

Ubiquitous. Highest levels in brain, testis and ovary.

Target Synonyms

CAMLG; CAML; Calcium signal-modulating cyclophilin ligand; CAML

Target Background

The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin.