Recombinant Human Calmodulin-like protein 5 (CALML5)

Uniprot Id

Q9NZT1

Target Species

Human

Target Name

CALML5

Target Full Name

Calmodulin-like protein 5

Target Function

Binds calcium. May be involved in terminal differentiation of keratinocytes.

Target Tissue Specificity

Particularly abundant in the epidermis where its expression is directly related to keratinocyte differentiation. Very low expression in lung.

Target Research Area

Cell Biology

Target Synonyms

CALL5_HUMAN; CALML5; Calmodulin like 5; Calmodulin-like protein 5; Calmodulin-like skin protein; CLSP

Target Background

This gene encodes a novel calcium binding protein expressed in the epidermis and related to the calmodulin family of calcium binding proteins. Functional studies with recombinant protein demonstrate it does bind calcium and undergoes a conformational change when it does so. Abundant expression is detected only in reconstructed epidermis and is restricted to differentiating keratinocytes. In addition, it can associate with transglutaminase 3, shown to be a key enzyme in the terminal differentiation of keratinocytes.