Recombinant Human Calmodulin-regulated spectrin-associated protein 1 (CAMSAP1), Truncated

Uniprot Id

Q5T5Y3

Target Species

Human

Target Name

CAMSAP1

Target Full Name

Calmodulin-regulated spectrin-associated protein 1

Target Function

Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization. Specifically recognizes growing microtubule minus-ends and stabilizes microtubules. Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization. In contrast to CAMSAP2 and CAMSAP3, tracks along the growing tips of minus-end microtubules without significantly affecting the polymerization rate: binds at the very tip of the microtubules minus-end and acts as a minus-end tracking protein (-TIP) that dissociates from microtubules after allowing tubulin incorporation. Through interaction with spectrin may regulate neurite outgrowth

Target Subcellular Location

Cytoplasm, cytoskeleton.

Target Protein Families

CAMSAP1 family

Target Synonyms

calmodulin regulated spectrin-associated protein 1; Calmodulin-regulated spectrin-associated protein 1; CAMP1_HUMAN; camsap1; PRO2405