Recombinant Human Calponin-2 (CNN2)

The recombinant Human CNN2 was expressed with the amino acid range of 2-309. This CNN2 protein is expected to have a theoretical molecular weight of 49.6 kDa. This CNN2 recombinant protein is manufactured in e.coli. The N-terminal 6xHis-SUMO tag was fused into the coding gene segment of CNN2, making it easier to detect and purify the CNN2 recombinant protein in the later stages of expression and purification.Human Calponin-2 (CNN2) is a cytoskeletal protein belonging to the calponin family, involved in the regulation of smooth muscle contraction and actin cytoskeleton organization. Encoded by the CNN2 gene, it is primarily expressed in smooth muscle tissues, such as those in the uterus, intestine, and vascular walls. CNN2 interacts with actin and calmodulin, influencing actin-myosin dynamics. Its role in smooth muscle contraction suggests implications in physiological processes like vascular tone and uterine contractions. Additionally, CNN2 has been associated with various diseases, including cancer, where its altered expression may contribute to tumor progression. The study of human CNN2 contributes to understanding smooth muscle function, cytoskeletal regulation, and its potential relevance in disease mechanisms.