Recombinant Human Caprin-2 (CAPRIN2), Truncated

Uniprot Id

Q6IMN6

Target Species

Human

Target Name

CAPRIN2

Target Full Name

Caprin-2

Target Function

Promotes phosphorylation of the Wnt coreceptor LRP6, leading to increased activity of the canonical Wnt signaling pathway. Facilitates constitutive LRP6 phosphorylation by CDK14/CCNY during G2/M stage of the cell cycle, which may potentiate cells for Wnt signaling. May regulate the transport and translation of mRNAs, modulating for instance the expression of proteins involved in synaptic plasticity in neurons. Involved in regulation of growth as erythroblasts shift from a highly proliferative state towards their terminal phase of differentiation. May be involved in apoptosis.

Target Subcellular Location

[Isoform 1]: Cytoplasm.; [Isoform 2]: Mitochondrion. Cytoplasm. Note=Expressed throughout the cytoplasm.; [Isoform 5]: Mitochondrion. Note=Colocalizes with aggregated mitochondria.; Cell membrane; Peripheral membrane protein.

Target Protein Families

Caprin family

Target Tissue Specificity

Detected in all tissues tested with highest levels of expression in brain and spleen.

Target Synonyms

C1q domain-containing protein 1; C1QDC1; CAPR2_HUMAN; Caprin family member 2; Caprin-2; caprin2; Cytoplasmic activation/proliferation-associated protein 2; EEG 1; EEG1; Gastric cancer multidrug resistance-associated protein; KIAA1873; Protein EEG-1; RNA granule protein 140; RNG140

Target Background

The protein encoded by this gene may regulate the transport of mRNA. It may play a role in the differentiation of erythroblasts. Multiple transcript variants encoding different isoforms have been found for this gene.