Recombinant Human Carbonic anhydrase 14 (CA14), Truncated

Uniprot Id

Q9ULX7

Target Species

Human

Target Name

CA14

Target Full Name

Carbonic anhydrase 14

Target Function

Reversible hydration of carbon dioxide.

Target Subcellular Location

Membrane; Single-pass type I membrane protein.

Target Protein Families

Alpha-carbonic anhydrase family

Target Tissue Specificity

High expression in all parts of the central nervous system and lower expression in adult liver, heart, small intestine, colon, kidney, urinary bladder and skeletal muscle.

Target Synonyms

CA 14; CA XIV; CA-XIV; CA14; CAH14_HUMAN; Carbonate dehydratase XIV; Carbonic anhydrase 14; Carbonic anhydrase XIV; Carbonic dehydratase; CAXIV; UNQ690/PRO1335

Target Background

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA XIV is predicted to be a type I membrane protein and shares highest sequence similarity with the other transmembrane CA isoform, CA XII; however, they have different patterns of tissue-specific expression and thus may play different physiologic roles.